Protein binding specificity versus promiscuity
نویسندگان
چکیده
منابع مشابه
Protein binding specificity versus promiscuity.
Interactions between macromolecules in general, and between proteins in particular, are essential for any life process. Examples include transfer of information, inhibition or activation of function, molecular recognition as in the immune system, assembly of macromolecular structures and molecular machines, and more. Proteins interact with affinities ranging from millimolar to femtomolar and, b...
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Drug repositioning applies established drugs to new disease indications with increasing success. A pre-requisite for drug repurposing is drug promiscuity (polypharmacology) - a drug's ability to bind to several targets. There is a long standing debate on the reasons for drug promiscuity. Based on large compound screens, hydrophobicity and molecular weight have been suggested as key reasons. How...
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fails to resolve, demonstrating that, as with the selection of other neural precursors, the resolution of amos expression involves lateral inhibition. In the antennal imagi-nal disc, amos mRNA is detected in three semicircular The peripheral nervous system (PNS) is made up of an bands that correspond to the sites where olfactory sen-array of different sensory structures that detect aspects sill...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2011
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2010.10.002